Related Experiment Video
Updated: May 21, 2026

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
Shaping the landscape: metabolic regulation of S1P gradients
Ana Olivera1, Maria Laura Allende, Richard L Proia
1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA. oliveraa@mail.nih.gov.
Abstract:
Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when compartments with differing extracellular S1P concentrations are formed that serve to regulate functions within the immune and vascular systems, as well as during pathologic conditions. Gradients of S1P concentration are achieved by the organization of cells with specialized expression of S1P metabolic pathways within tissues. S1P concentration gradients underpin the ability of S1P signaling to regulate in vivo physiology. This review will discuss the mechanisms that are necessary for the formation and maintenance of S1P gradients, with the aim of understanding how a simple lipid controls complex physiology. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
Related Concept Videos
Global Regulatory Systems
Regulation of Metabolism
Translational Regulation
Secondary Active Transport
Secondary Active Transport
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

