Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regional anesthesia for hysterectomies across a large healthcare system: location matters.

BMC anesthesiology·2026
Same author

Occupational Risk of Low-Level Blast Exposure and Health Outcomes: A Longitudinal Study of Postdeployment Army Enlisted Active Duty Soldiers.

The Journal of head trauma rehabilitation·2026
Same author

Dry Needling in the Military Health System: A Retrospective Observational Study.

Military medicine·2026
Same author

Contraceptive Access for Active Duty Service Women: Evaluation of Women and Infant Community Care Clinics in the Military Health System.

Military medicine·2026
Same author

Predictors of General Anesthesia Receipt During Cesarean Deliveries in the U.S. Military Health System: A Retrospective Cohort Study.

Military medicine·2026
Same author

Dexmedetomidine Receipt and Postanesthesia Care Unit Duration in the U.S. Military Health System.

Anesthesiology·2026

Related Experiment Video

Updated: May 21, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner.

Scott F Stoltenberg1, Christa C Christ, Krista B Highland

  • 1Behavior Genetics Laboratory, Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588‐0308, USA. sstoltenberg2@unl.edu

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|June 28, 2012
PubMed
Summary

Genetic factors influence impulsivity, with significant interactions found between gender and specific gene variants, as well as gene-gene interactions. Early life trauma also plays a role in these complex genetic effects.

More Related Videos

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Related Experiment Videos

Last Updated: May 21, 2026

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

Area of Science:

  • Neurogenetics
  • Behavioral Genetics
  • Psychiatric Genetics

Background:

  • Impulsivity is a significant risk factor for adverse outcomes, including psychiatric disorders and suicide.
  • Genetic variations are known to influence individual differences in impulsivity, but the precise mechanisms remain unclear.
  • Context-dependent genetic effects, such as gender specificity, gene-environment, and gene-gene interactions, are increasingly recognized as important.

Purpose of the Study:

  • To investigate the associations between polymorphisms in serotonin system genes, early life trauma, and individual differences in impulsivity.
  • To examine potential gender-specific, gene-gene (epistatic), and gene-environment interactions influencing impulsivity.

Main Methods:

  • Cross-sectional study of 424 non-clinical Caucasian university students.
  • Assessed impulsivity using the Barratt Impulsiveness Scale (BIS-11).
  • Analyzed polymorphisms in six serotonin system candidate genes and the experience of early life trauma (ages 0-12).

Main Results:

  • Significant gender-gene interactions were observed for TPH2 (rs1386483) and HTR2A (rs6313) genotypes.
  • Significant epistatic interactions (gene-gene) were found among 5-HTTLPR and MAOA uVNTR, 5-HTTLPR and rs6313, and HTR1B (rs6296) and rs6313 genotypes.
  • These interactions were significant at p<.01 and False Discovery Rate <.10.

Conclusions:

  • Results strongly support the investigation of context-dependent genetic effects on impulsivity.
  • Findings may help reconcile conflicting reports in the existing literature on impulsivity genetics.
  • Highlights the complex interplay of genetics, gender, and early life experiences in shaping impulsivity.