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Related Experiment Video

Updated: May 21, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Uveitis in seronegative arthritis.

Daniel Wendling1

  • 1Department of Rheumatology, University Teaching Hospital, and University of Franche-Comté, Besançon, France. dwendling@chu-besancon.fr

Current Rheumatology Reports
|June 28, 2012
PubMed
Summary
This summary is machine-generated.

Uveitis is common in spondyloarthritis, linked to HLA-B27. Targeting the IL-23/IL-17 pathway shows promise for treating both uveitis and rheumatic conditions.

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Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Uveitis is a frequent extra-articular manifestation in seronegative arthritis, impacting up to one-third of spondyloarthritis patients.
  • Its occurrence is associated with HLA-B27, disease duration, and potentially infectious episodes, inflammatory bowel disease, and cervical spine involvement.
  • The IL-23/IL-17 pathway is implicated in spondyloarthritis and its associated uveitis.

Purpose of the Study:

  • To review the role of the IL-23/IL-17 pathway in spondyloarthritis-related uveitis.
  • To evaluate current and potential therapeutic strategies for managing uveitis in spondyloarthritis.

Main Methods:

  • Literature review of studies on uveitis in spondyloarthritis.
  • Analysis of data concerning treatment outcomes with NSAIDs, DMARDs, anti-TNF agents, and other biologics.
  • Examination of the IL-23/IL-17 pathway's involvement.

Main Results:

  • Uveitis prevalence in spondyloarthritis is significant, with links to specific clinical and genetic factors.
  • NSAIDs, DMARDs, and anti-TNF therapies can reduce uveitis flares.
  • New-onset uveitis has been observed during anti-TNF therapy, suggesting complex immune responses.

Conclusions:

  • The IL-23/IL-17 pathway is a key factor in spondyloarthritis and associated uveitis.
  • IL-17 blockade presents a potential novel therapeutic strategy for managing both conditions concurrently.
  • Further research into biologic agents beyond anti-TNF is warranted for uveitis in spondyloarthritis.