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Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Isolation of Quiescent Stem Cell Populations from Individual Skeletal Muscles
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Published on: December 9, 2022

Stem cell powwow in Squaw Valley.

Ian Chambers1, Timm Schroeder

  • 1MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK. chambers@ed.ac.uk

Development (Cambridge, England)
|June 28, 2012
PubMed
Summary

This review summarizes key advances in stem cell biology, covering stem cell origins, development, and death. It highlights new findings from a 2012 Keystone Symposium on stem cell research.

Area of Science:

  • Stem Cell Biology
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Stem cells are crucial for development and tissue repair.
  • Understanding stem cell lifecycles is essential for therapeutic applications.
  • Recent scientific meetings convene global experts to share cutting-edge research.

Purpose of the Study:

  • To review the proceedings of the 'Life of a Stem Cell: from Birth to Death' Keystone Symposium.
  • To highlight major advances in fundamental and applied stem cell biology presented at the meeting.
  • To synthesize recent developments in the field of stem cell research.

Main Methods:

  • Review of presentations and discussions from the 2012 Keystone Symposium.
  • Synthesis of emerging findings in stem cell biology.

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  • Analysis of advancements in both basic and translational stem cell research.

    • Main Results:

    • Showcased the most recent developments in stem cell research.
    • Identified major advances in understanding stem cell origins, proliferation, differentiation, and senescence.
    • Highlighted progress in applying stem cell knowledge to various biological and medical fields.

    Conclusions:

    • The symposium provided a comprehensive overview of the current state of stem cell biology.
    • Significant progress has been made in understanding the complete lifecycle of stem cells.
    • Future research directions and therapeutic potentials were discussed, emphasizing the dynamic nature of the field.