Related Experiment Video

Updated: May 21, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Periventricular venous density in multiple sclerosis is inversely associated with T2 lesion count: a 7 Tesla MRI

Tim Sinnecker1, Ivan Bozin, Jan Dörr

  • 1NeuroCure Clinical Research Center, Charité - University Medicine Berlin, Germany.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|June 28, 2012
PubMed
Abstract

Insights

Decreased small blood vessel density in the brain is evident in early multiple sclerosis (MS) and clinically isolated syndrome. This finding, observed with 7 Tesla MRI, correlates with lesion load but not venous congestion.

Area of Science:

  • Neuroimaging
  • Vascular Biology
  • Neurology

Background:

  • Venular damage in multiple sclerosis (MS) has been recognized for decades.
  • Ultrahigh magnetic field strength T2*-weighted magnetic resonance imaging (MRI) now allows detailed visualization of small cerebral veins in vivo.

Purpose of the Study:

  • To investigate alterations in periventricular small blood vessel appearance in MS and clinically isolated syndrome (CIS) using 7 Tesla MRI.
  • To compare these alterations with T2 lesion count and distribution in patients and healthy controls.

Main Methods:

  • 38 patients (16 early MS, 7 CIS) and 22 healthy controls underwent 7 Tesla MRI.
  • T2*-weighted Fast Low Angle Shot and T2-weighted Turbo Inversion Recovery Magnitude sequences were utilized.
  • A novel region-of-interest-based algorithm quantified periventricular venous density and vascular area.

Main Results:

  • Significantly decreased venous density was observed in MS patients compared to controls.
  • Venous alterations were detectable, albeit to a lesser extent, in CIS and early MS.
  • Venous density showed an inverse correlation with periventricular and whole-brain T2 lesion count.
  • No evidence of cerebral venous congestion was found in MS patients.

Conclusions:

  • High-resolution T2*-weighted MRI reveals vascular changes in early MS stages.
  • These vascular alterations are likely part of broader hemodynamic and metabolic changes in MS.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...