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Increased Body Temperature

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A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

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Malignant hyperthermia in endosulfan poisoning.

Gaurav Jain¹, Dinesh K Singh, Ghanshyam Yadav

¹Department of Anesthesia and Intensive care, IMS, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Toxicology International

|June 28, 2012

Summary

Endosulfan poisoning can trigger malignant hyperthermia (MH), a rare and life-threatening condition. Early recognition of symptoms like fever and muscle rigidity is crucial for timely diagnosis and treatment.

Keywords:

Endosulfan malignant hyperthermia poisoning seizure

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Area of Science:

Toxicology
Anesthesiology
Emergency Medicine

Background:

Endosulfan, an organochlorine pesticide, is known for its neurotoxic effects.
Malignant hyperthermia (MH) is a severe pharmacogenetic disorder of skeletal muscle.

Observation:

A patient with endosulfan poisoning presented with altered consciousness, vomiting, and seizures.
Sudden physiological deterioration including elevated EtCO2, vital signs, and body temperature occurred 8 hours post-admission.
Clinical signs of muscle rigidity, including masseter spasm and inability to flex limbs, were observed.

Findings:

The clinical presentation in the context of endosulfan poisoning was suggestive of MH.
A positive caffeine halothane contraction test confirmed the diagnosis of malignant hyperthermia (MH).

Implications:

This case highlights a potential, previously unrecognized association between endosulfan poisoning and MH.
Clinicians should consider MH in patients with endosulfan poisoning exhibiting unexplained hyperthermia and muscle rigidity.
Prompt diagnosis and management of MH are critical for improving patient outcomes in toxicological emergencies.