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Assessing Human Spatial Navigation in a Virtual Space and its Sensitivity to Exercise

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Spatial navigation-a unique window into physiological and pathological aging.

Ivana Gazova¹, Kamil Vlcek, Jan Laczó

¹Department of Neurology, Memory Disorders Clinic, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol Prague 5, Czech Republic.

Frontiers in Aging Neuroscience

|June 28, 2012

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Severe spatial navigation deficits can signal early Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Spatial navigation testing offers a crucial opportunity for the early diagnosis of AD.

Area of Science:

Neuroscience
Cognitive Psychology
Gerontology

Background:

Spatial navigation, the ability to determine and maintain a trajectory, naturally declines with age.
Severe deficits in spatial navigation can be an early indicator of Alzheimer's disease (AD), appearing at the mild cognitive impairment (MCI) stage.

Purpose of the Study:

To investigate the role of spatial navigation deficits in the early detection of Alzheimer's disease (AD).
To explore the potential of spatial navigation testing for identifying individuals at high risk for AD, particularly those with amnestic MCI.

Main Methods:

Assessment of spatial navigation skills in elderly individuals.
Development and utilization of computer-based tests for routine clinical assessment of spatial navigation.

Keywords:

Alzheimer's disease allocentric navigation egocentric navigation mild cognitive impairment pathological ageing physiological ageing spatial navigation

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Main Results:

Patients with amnestic MCI, especially those with hippocampal involvement, exhibit spatial navigation impairment patterns similar to those with mild AD.
Spatial navigation testing shows promise in identifying individuals with MCI who are at high risk for developing AD.

Conclusions:

Spatial navigation impairment is a significant early marker for Alzheimer's disease (AD).
Clinical and computer-based spatial navigation tests can serve as valuable tools for the early diagnosis of AD in individuals with mild cognitive impairment (MCI).