Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus.

Neuroscience research·2025

Same author

Data report on gene expression after hepatic portal vein ligation (PVL) in rats.

Frontiers in genetics·2024

Same author

Approaching Thrombospondin-1 as a Potential Target for Mesenchymal Stromal Cells to Support Liver Regeneration after Partial Hepatectomy in Mouse and Humans.

Cells·2024

Same author

Organotypic 3D Co-Culture of Human Pleura as a Novel In Vitro Model of <i>Staphylococcus aureus</i> Infection and Biofilm Development.

Bioengineering (Basel, Switzerland)·2023

Same author

Periportal steatosis in mice affects distinct parameters of pericentral drug metabolism.

Scientific reports·2022

Same author

Novel 3D organotypic co-culture model of pleura.

PloS one·2022

Search research articles

Related Experiment Video

Updated: May 21, 2026

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Mesenchymal stem cell-derived hepatocytes for functional liver replacement.

Bruno Christ¹, Peggy Stock

¹Applied Molecular Hepatology Laboratory, Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig Leipzig, Germany.

Frontiers in Immunology

|June 28, 2012

Summary

This summary is machine-generated.

Mesenchymal stem cells (MSCs) can become liver cells and support liver repair. These stem cells offer a promising alternative for liver transplantation and regeneration therapies.

Keywords:

cell transplantation hepatocyte liver mesenchymal stem cells

More Related Videos

Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells

Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells

Published on: March 2, 2017

Semi-automated Production of Hepatocyte Like Cells from Pluripotent Stem Cells

Semi-automated Production of Hepatocyte Like Cells from Pluripotent Stem Cells

Published on: July 27, 2018

Related Experiment Videos

Last Updated: May 21, 2026

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells

Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells

Published on: March 2, 2017

Semi-automated Production of Hepatocyte Like Cells from Pluripotent Stem Cells

Semi-automated Production of Hepatocyte Like Cells from Pluripotent Stem Cells

Published on: July 27, 2018

Area of Science:

Regenerative Medicine
Hepatology
Stem Cell Biology

Background:

Primary hepatocytes face limitations in transplantation due to availability and differentiation challenges.
Mesenchymal stem cells (MSCs) offer a potential alternative due to their differentiation capacity and abundance.

Purpose of the Study:

To evaluate MSCs as a substitute for hepatocytes in transplantation.
To investigate the differentiation potential and functional maintenance of MSCs into hepatocyte-like cells.
To explore the mechanisms by which MSCs support liver regeneration.

Main Methods:

In vitro differentiation of MSCs into hepatocyte-like cells.
In vivo transplantation of MSCs into rodent liver models (mice and rats).
Assessment of MSC function under both injury and non-injury conditions.

Main Results:

MSCs successfully differentiate into hepatocyte-like cells in vitro.
Transplanted MSCs maintain hepatocyte-like functions in vivo in regenerating livers.
MSCs exhibit therapeutic effects by replacing diseased tissue or supporting regeneration.

Conclusions:

Mesenchymal stem cells are a viable alternative to primary hepatocytes for liver transplantation.
MSCs promote liver regeneration through anti-inflammatory, anti-apoptotic, and pro-proliferative actions.
MSC-based therapies hold promise for treating various liver diseases.