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Nickel-Catalyzed Regiodivergent Approach to Macrolide Motifs
Abdur-Rafay Shareef1, David H Sherman, John Montgomery
1Department of Chemistry, 930 N. University Ave. University of Michigan, Ann Arbor, MI 48109-1055.
Abstract:
A strategy for regiochemical reversal of reductive macrocyclizations of aldehydes and terminal alkynes has been developed. Using an advanced synthetic intermediate directed towards the methymycin/neomethymycin class of macrolides, selective endocyclization provides the natural twelve-membered ring series, whereas ligand alteration enables selective exocyclization to provide access to the unnatural eleven-membered ring series. The twelve-membered ring adduct was converted to 10-deoxymethynolide, completing an efficient total synthesis of this natural product.
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