Related Experiment Video
Updated: May 21, 2026
08:06
Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model
Published on: November 26, 2010
Egfl7 promotes tumor escape from immunity.
Sébastien Pinte1, Fabrice Soncin1
1CNRS UMR8161; Institut de Biologie de Lille; Lille, France.
Oncoimmunology
|June 28, 2012
Summary
Epidermal growth factor-like 7 (Egfl7) helps tumors evade immune detection. It reduces immune cell entry into tumors by decreasing adhesion molecule expression in blood vessels.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Epidermal growth factor-like 7 (Egfl7) is an endothelial-specific gene.
- Egfl7 expression is altered in various human cancers.
Purpose of the Study:
- To investigate the role of Egfl7 in tumor immune evasion.
- To elucidate the mechanism by which Egfl7 influences immune cell infiltration.
Main Methods:
- Analysis of Egfl7 expression in cancer tissues.
- In vitro studies on endothelial cells to assess leukocyte adhesion molecule expression.
- Experiments to evaluate immune cell extravasation into tumors.
Main Results:
- Egfl7 expression is deregulated in human cancers.
- Egfl7 downregulates leukocyte adhesion molecules in endothelial cells.
- This downregulation inhibits immune cell extravasation into tumors, promoting immune escape.
Conclusions:
- Egfl7 plays a significant role in facilitating tumor immune evasion.
- Targeting Egfl7 may represent a novel strategy to enhance anti-tumor immunity.
Related Concept Videos
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:38Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
02:23Abnormal Proliferation
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...