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Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Published on: September 12, 2011
Comparison of brain apparent diffusion coefficient value in naturally and assisted conceived newborns
Mehmet Aslan1, Metin Dogan, Onder Celik
1Department of Pediatrics, Inonu University School of Medicine, Turgut Ozal Medical Center, 44315, Malatya, Turkey. mehmetaslan222@gmail.com
Background:
Our aim was to assess the value of brain apparent diffusion coefficient (ADC) in Intra Cytoplasmic Sperm Injection (ICSI) and spontaneously conceived preterm singletons.
Methods:
Twenty ICSI-conceived preterm singletons and 20 gestational age matched spontaneously conceived preterm singletons were studied. All subjects underwent diffusion-weighted imaging (DWI). The main outcome measure was the brain ADC value in the in ICSI-conceived and naturally conceived newborns.
Results:
Children born after ICSI had an increased ADC value than the controls. The ADC values of ICSI-conceived singletons were higher than those of spontaneously conceived singletons at cerebellum, corpus striatum, frontal lobe, occipital lobe, and temporal lobe white matter. The mean Apgar score, birth weight, height, and head circumference of ICSI children were found to be similar to naturally conceived children.
Conclusions:
Measuring ADC value may be a promising marker in identifying neurological outcome of ICSI-conceived newborns.
