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Updated: May 21, 2026

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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Life course pathways to prenatal maternal stress
Summary
Childhood and adult stressors significantly impact perceived stress during pregnancy. Factors like family cohesion and socioeconomic position play crucial roles across the lifespan, influencing prenatal stress levels.
Area of Science:
- Psychology
- Public Health
- Sociology
Background:
- Prenatal stress is a significant concern with potential adverse outcomes for both mother and child.
- Understanding the origins of prenatal stress, including early life experiences, is crucial for effective intervention.
- Previous research has explored various risk factors, but the interplay of childhood and adult stressors requires further investigation.
Purpose of the Study:
- To examine the influence of recalled childhood stressors and adult stressors on perceived stress during pregnancy.
- To identify specific childhood factors (e.g., family cohesion, social support, socioeconomic position) and their pathways to prenatal stress.
- To assess the direct and indirect effects of adult factors on perceived prenatal stress.
Main Methods:
- Prospective cohort study design involving 421 pregnant women.
- Recruitment from pre-birth clinics in two diverse communities.
- Statistical analysis to determine associations between recalled childhood stress, adult factors, and perceived prenatal stress, controlling for covariates.
Main Results:
- Recalled childhood stress showed a positive association with prenatal stress (β = .54) after adjustments.
- Low childhood family cohesion indirectly impacted prenatal stress via recalled stress, current cohesion, and socioeconomic position (SEP).
- Low adult subjective SEP (β = -.44) and family cohesion (β = -.25) were directly linked to higher prenatal stress.
Conclusions:
- Prenatal stress arises from a complex interaction between childhood experiences and adult circumstances.
- Findings highlight the importance of lifelong psychosocial risk assessment and interventions to mitigate prenatal stress.
- Interventions targeting early life adversities and current adult factors may reduce adverse pregnancy outcomes.
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