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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

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Intra-lymph Node Injection of Biodegradable Polymer Particles
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Revolutionizing drug delivery through biodegradable multilayered particles.

Wei Li Lee1, Say Chye Joachim Loo

  • 1School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave., Singapore, Singapore.

Journal of Drug Targeting
|June 29, 2012
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Multilayered microparticles offer enhanced control over drug release kinetics, overcoming limitations of single-layered systems for potent therapeutics. These advanced delivery systems enable fine-tuned release profiles, including pulsatile and time-delayed options.

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Modern drug discovery yields potent agents with narrow therapeutic windows, demanding improved drug delivery systems.
  • Conventional single-layered polymeric particles exhibit limited control over drug release, showing burst release and lacking pulsatile or zero-order kinetics.
  • Need for advanced particulate drug delivery systems to manage complex drug release profiles and multiple drug combinations.

Purpose of the Study:

  • To provide an overview of fabrication and characterization techniques for multilayered polymeric microparticles.
  • To focus on the one-step solvent evaporation technique and its critical process parameters influencing microparticle formation.
  • To discuss the benefits and challenges associated with multilayered microparticulate systems for drug delivery applications.

Main Methods:

  • Review of fabrication techniques for multilayered polymeric microparticles.
  • Detailed examination of the one-step solvent evaporation method.
  • Analysis of process parameters affecting microparticle structure and drug release.

Main Results:

  • Multilayered microparticles offer superior control over drug release kinetics compared to single-layered systems.
  • The one-step solvent evaporation technique allows for tailored microparticle configurations.
  • Distinct structural attributes and degradation behaviors of multilayered systems can be leveraged for controlled drug release.

Conclusions:

  • Multilayered microparticulate systems represent a significant advancement in drug delivery, addressing limitations of conventional approaches.
  • Exploiting structural and degradation properties enables fine-tuning of drug release profiles for enhanced therapeutic efficacy.
  • These systems hold promise for delivering potent drugs with narrow therapeutic windows and achieving complex release patterns.