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Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Published on: August 30, 2018

Safe prescribing: a titanic challenge.

Philip A Routledge1

  • 1Department of Pharmacology, Therapeutics and Toxicology, Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, United Kingdom. routledgepa@cardiff.ac.uk

British Journal of Clinical Pharmacology
|June 29, 2012
PubMed
Summary
This summary is machine-generated.

Achieving safe prescribing requires addressing organizational and human errors, similar to the Titanic disaster. A commitment to excellence, lifelong learning, and a strong safety culture are crucial for optimal medication use and patient safety.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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05:10

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Published on: December 11, 2016

Area of Science:

  • Medical Safety
  • Pharmacology
  • Healthcare Management

Background:

  • Safe prescribing is a significant challenge in healthcare.
  • Organizational and human errors contribute to prescribing issues like underprescribing, overprescribing, and medication errors.
  • These errors share parallels with factors leading to historical accidents, such as the Titanic tragedy.

Purpose of the Study:

  • To highlight the critical importance of safe prescribing practices.
  • To identify key factors that undermine safe prescribing.
  • To propose strategies for improving prescribing safety and patient outcomes.

Main Methods:

  • Comparative analysis of prescribing errors and historical accident factors.
  • Discussion of contributing elements such as communication failures, complacency, and lack of courage.
  • Emphasis on the 'Seven C's' framework for excellence in prescribing.

Main Results:

  • Medication errors frequently occur during the prescribing stage.
  • Factors like poor communication, environmental imperfections, and human fallibility contribute to errors.
  • Optimal prescribing necessitates collaboration, continuous learning, and a robust safety culture.

Conclusions:

  • A commitment to excellence, encompassing lifelong learning and interprofessional collaboration, is vital for safe prescribing.
  • Improving the clinical working environment and fostering a strong safety culture are essential.
  • Encouraging interprofessional challenge and accountability ensures prescribing maximizes benefit while minimizing harm.