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Updated: May 21, 2026

Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking
Published on: October 23, 2019
CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms
Elisabeth Oppliger Leibundgut1, Daniela Rogenmoser-Dissler, Dirk de Beer
1Department of Hematology, University Hospital and University of Bern, Bern, Switzerland. elisabeth.oppliger@insel.ch
Abstract:
The distinction of CLL from other mature B-cell neoplasms, especially from leukemic forms of mantle cell lymphoma or splenic marginal zone lymphoma, can be difficult but has important prognostic and therapeutic implications. We measured CLLU1 (CLL upregulated gene1) mRNA by qPCR and found a highly significant difference between CLL and other lymphoid neoplasms (AUC 0.96, 95%CI 0.93-0.99). Based on our cut-off values we can predict CLL and other mature B-cell neoplasms with high probability (PPV 99% and 94%). Analysis of CLLU1 expression is a rapid and reliable tool that may facilitate the diagnosis of mature B-cell neoplasms especially in inconclusive cases.
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