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Stroke patients with cerebral microbleeds on MRI scans have arteriolosclerosis as well as systemic atherosclerosis

Takashi Shimoyama1, Yasuyuki Iguchi, Kazumi Kimura

  • 1Department of Neurology, Jikei University School of Medicine, Tokyo, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|June 29, 2012
PubMed

Insights

Cerebral microbleeds (CMBs) in stroke patients are linked to systemic atherosclerosis, measured by cardio-ankle vascular index (CAVI). High CAVI, white matter hyperintensity, and kidney dysfunction independently predict CMBs.

Area of Science:

  • Neurology
  • Cardiology
  • Vascular Medicine

Background:

  • Cerebral microbleeds (CMBs) indicate cerebral small vessel disease.
  • The association between CMBs and systemic atherosclerosis remains unclear.

Purpose of the Study:

  • To investigate the relationship between CMBs and systemic atherosclerosis using cardio-ankle vascular index (CAVI) in acute ischemic stroke patients.

Main Methods:

  • Prospective study of 105 acute ischemic stroke patients.
  • Assessment of CMBs and white matter hyperintensity (WMH) using MRI.
  • Measurement of systemic atherosclerosis using CAVI.

Main Results:

  • CMBs were present in 44.8% of patients.
  • Patients with CMBs had significantly higher CAVI.
  • High CAVI, advanced WMH, and impaired kidney function were independent predictors of CMBs.

Conclusions:

  • Cardio-ankle vascular index (CAVI) is independently associated with CMBs in acute ischemic stroke patients.
  • CMBs may signify both cerebral arteriolosclerosis and systemic atherosclerosis.

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