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Semi-Automated Analysis of Peak Amplitude and Latency for Auditory Brainstem Response Waveforms Using R

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Auditory system dysfunction due to infantile thiamine deficiency: long-term auditory sequelae.

J Attias¹, E Raveh, A Aizer-Dannon

¹Department of Communication Sciences and Disorders, University of Haifa, Haifa, Israel. attiasj@netvision.net.il

Audiology & Neuro-Otology

|June 29, 2012

Summary

Thiamine deficiency in infants can cause auditory neuropathy spectrum disorder (ANSD) and hearing loss. Supplementation can resolve ANSD, but long-term developmental delays may persist.

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Infant Auditory Processing and Event-related Brain Oscillations

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Area of Science:

Pediatrics
Neuroscience
Otolaryngology

Background:

Thiamine (Vitamin B1) is essential for neural development and function.
Infant nutrition plays a critical role in auditory system development.
Auditory neuropathy spectrum disorder (ANSD) presents diagnostic challenges in infants.

Purpose of the Study:

To evaluate immediate and long-term auditory abnormalities in infants with thiamine deficiency.
To investigate the impact of thiamine supplementation on auditory outcomes.
To establish thiamine deficiency as a potential acquired metabolic cause of ANSD.

Main Methods:

Retrospective evaluation of eleven infants fed a thiamine-deficient formula.
Auditory assessments including audiograms and brainstem auditory evoked potentials.
Long-term follow-up (6-8 years) assessing auditory and language development.

Main Results:

Eight of eleven infants presented with auditory neuropathy spectrum disorder (ANSD).
Five infants with ANSD showed resolution with thiamine supplementation; two had permanent hearing loss.
Survivors experienced language delays and impaired speech intelligibility, particularly with background noise.

Conclusions:

Thiamine deficiency is a significant acquired metabolic cause of ANSD in infants.
Early thiamine supplementation can reverse ANSD in some cases.
Long-term auditory and speech deficits necessitate ongoing developmental monitoring.