Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

Automated Microbial Diagnostics

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

In Vitro Drug Release Testing: Overview, Development and Validation

In Vitro Drug Release Testing: Overview, Development and Validation

In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Traceable localization enables accurate integration of quantum emitters and photonic structures with high yield.

Optica quantum·2024

Same author

Letter to the Editor Concerning "Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles".

ACS nano·2023

Same author

Unmasking the Resolution-Throughput Tradespace of Focused-Ion-Beam Machining.

Advanced functional materials·2023

Same author

Sub-picoliter Traceability of Microdroplet Gravimetry and Microscopy.

Analytical chemistry·2021

Same author

The Nanolithography Toolbox.

Journal of research of the National Institute of Standards and Technology·2021

Same author

Accurate localization microscopy by intrinsic aberration calibration.

Nature communications·2021

Search research articles

Related Experiment Video

Updated: May 21, 2026

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

A glowing future for lab on a chip testing standards.

Samuel M Stavis¹

¹Semiconductor and Dimensional Metrology Division, Physical Measurement Laboratory, National Institute of Standards and Technology, 100 Bureau Drive, MS 8120, Gaithersburg, Maryland, USA. sstavis@nist.gov

|June 29, 2012

Summary

This summary is machine-generated.

Developing testing standards for lab on a chip technology, focusing on autofluorescence, offers a less controversial path to commercialization. This approach is crucial for sensitive fluorescence measurements in plastic microfluidic devices.

More Related Videos

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Microfluidic Applications for Disposable Diagnostics

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

Related Experiment Videos

Last Updated: May 21, 2026

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Microfluidic Applications for Disposable Diagnostics

Microfluidic Applications for Disposable Diagnostics

Published on: February 3, 2008

Area of Science:

Metrology
Materials Science
Biotechnology

Background:

Lab on a chip (LOC) technology requires standardization for widespread adoption.
Product standards present industrial challenges, making testing standards a more viable route.
Autofluorescence in microfluidic and nanofluidic devices is a critical material property for sensitive measurements.

Purpose of the Study:

To explore the development of a lab on a chip testing standard.
To contextualize this development within the issue of autofluorescence.
To facilitate the standardization and commercialization of LOC technology.

Main Methods:

Focus article reviewing the development of testing standards.
Analysis of autofluorescence in the context of LOC standardization.
Consideration of material properties in plastic microfluidic devices.

Main Results:

Testing standards are metrologically fundamental and industrially less controversial than product standards.
Autofluorescence is a key consideration for sensitive fluorescence measurements in plastic LOC devices.
Standardization of testing protocols is a critical step for commercializing LOC technology.

Conclusions:

Developing testing standards, particularly addressing autofluorescence, is a pragmatic approach for advancing lab on a chip commercialization.
Standardized testing facilitates reliable and sensitive fluorescence measurements in plastic microfluidic devices.
This strategy offers a path of less resistance for integrating LOC technology into various applications.