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Tritium-labeled brivaracetam with high specific activity: preparation, characterization and application in human

Simone Hildenbrand1, Susanne Schoch, Marec von Lehe

  • 1Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

Chemmedchem
|June 29, 2012
PubMed
Abstract

No abstract available in PubMed .

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...