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Cardiomyopathy III: Hypertrophic Cardiomyopathy

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

Cardiomyopathy I: Introduction and Classification

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Mitral Regurgitation I: Introduction

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Related Experiment Video

Updated: May 21, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

Published on: June 16, 2023

Hypoplastic right-heart syndrome presenting as multiple miscarriages.

Chadi Dib¹, Philip A Araoz, Norman P Davies

¹Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Texas Heart Institute Journal

|June 29, 2012

Summary

A rare congenital heart defect caused repeated miscarriages due to hypoxemia. Successful surgical repair resolved symptoms, enabling a healthy pregnancy and delivery.

Keywords:

Abortion, spontaneous/etiology heart defects, congenital/complications/physiopathology/therapy/surgery treatment outcome ventricular function, right/physiology

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Last Updated: May 21, 2026

Left Atrial Ligation in the Avian Embryo as a Model for Altered Hemodynamic Loading During Early Vascular Development

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Published on: June 16, 2023

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Published on: May 5, 2018

Area of Science:

Cardiology
Reproductive Medicine
Medical Case Reports

Background:

Recurrent miscarriages affect a small percentage of women trying to conceive.
Identifying reversible causes is crucial for successful pregnancy outcomes.
Congenital heart defects can present atypically in adulthood.

Observation:

A 23-year-old woman experienced recurrent miscarriages.
She presented with hypoxemia and erythrocytosis.
Further investigation revealed hypoplastic right-heart syndrome with an intracardiac shunt.

Findings:

The patient underwent successful hybrid repair and surgical correction of her congenital heart defect.
Post-treatment, her hypoxemia and erythrocytosis resolved.
She subsequently achieved a successful full-term pregnancy and delivery.

Implications:

This case highlights a rare cause of recurrent pregnancy loss due to undiagnosed congenital heart disease.
Comprehensive medical evaluation is essential for women with unexplained recurrent miscarriages.
Timely diagnosis and intervention for congenital heart defects can restore reproductive health and improve outcomes.