Prevention of ACL injury, part I: injury characteristics, risk factors, and loading mechanism
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Updated: May 21, 2026

Non-Invasive Compression-Induced Anterior Cruciate Ligament (ACL) Injury and In Vivo Imaging of Protease Activity in Mice
Published on: September 29, 2023
Boyi Dai1, Daniel Herman, Hui Liu
1Center for Human Movement Science, Division of Physical Therapy, University of North Carolina, Chapel Hill, North Carolina 27599, USA. byu@med.unc.edu
Abstract:
The anterior cruciate ligament (ACL) injury is one of the most common injuries in sports. ACL injuries are not only costly from financial and health services consumption standpoints, but also can have devastating consequences on patients' activity levels and quality of life. Tremendous efforts have been made over the past two decades toward the goal of preventing ACL injuries. A substantial number of studies have been performed to determine the characteristics of ACL injury events, identify risk factors for ACL injury, and develop prevention strategies. The purpose of this review was to objectively summarize the current literature regarding the characteristics of ACL injury, ACL loading mechanisms, and risk factors for injury to provide a comprehensive understanding of the current state of research and how our current level of knowledge may inform clinical practice in this area.
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