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Updated: May 21, 2026
Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
Type-specific response to neoadjuvant chemotherapy: ovarian high-grade serous carcinoma versus colorectal mucinous
Sarah Glaze1, Jill Nation, Martin Köbel
1Division of Gynecologic Oncology, University of Calgary, Calgary AB.
Background:
Ovarian carcinomas are currently managed as a single entity with no stratification for histological type. The foundation of treatment is a combination of surgery and chemotherapy. Women who are not candidates for up-front debulking surgery, either because of performance status or widespread disease, are often offered neoadjuvant chemotherapy in an effort to shrink their tumour and make resection possible.
Case:
A 76-year-old woman was treated with neoadjuvant platinum-based chemotherapy for advanced ovarian cancer. At interval debulking surgery, she was found to have a concurrent mucinous colorectal carcinoma that was essentially unaffected by her treatment.
Conclusion:
This case serves as an in vivo demonstration of the greater resistance to platinum-based treatments of mucinous carcinomas than of the "typical" high-grade serous ovarian cancer.
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