Related Experiment Videos
Blood-brain barrier permeability: regional alterations after acute and chronic administration of ethinyl estradiol
Y Z Ziylan1, J M Lefauconnier, G Bernard
1Department of Physiology, Istanbul Faculty of Medicine, Turkey.
Neuroscience Letters
|October 16, 1990
Abstract:
In this study we measured the effect of acute and chronic estrogen treatment on cerebrovascular permeability to sucrose and inulin. Animals were subcutaneously injected once with 0.1 micrograms/rat of ethinyl estradiol or injected daily with the same drug dose for 3 weeks. Control rats received the same amount of arachis oil vehicle. Three weeks treatment but not the single injection of ethinyl estradiol produced significant increases in the cerebrovascular permeability-surface area product for sucrose and inulin in almost all brain regions.