Related Experiment Video
Updated: May 21, 2026
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
Published on: March 8, 2019
Reduced silicone oil adherence to silicone intraocular lens by surface modification with 2-methacryloyloxyethyl
Xiao-Dan Huang1, He-Yi Li, Lin Lin
1Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China.
Purpose:
to evaluate and compare the interaction of silicone oil-intraocular lens (IOLs) biomaterial in 2-methacryloyloxyethyl phosphoryl-choline (MPC) -modified IOLs and various widely used IOLs in vitro.
Methods:
Five groups of foldable IOLs, including 3-piece hydrophobic silicone IOLs, MPC-modified silicone IOLs, 3-piece hydrophilic hydrogel IOLs, one-piece hydrophilic acrylic IOLs and one-piece hydrophobic acrylic IOLs were photographed after immersion in silicone oil. The silicone oil coverage of the anterior and posterior surfaces of each IOL was measured using EPCO Image-analysis software. The hydrophilicity of the IOL surface was characterized by the water contact angle.
Results:
hydrophilic IOLs, such as MPC-modified silicone IOLs, hydrophilic acrylic IOLs and hydrogel IOLs having a lower contact angle exhibited less silicone oil adherence than hydrophobic IOLs, including both silicone IOLs and hydrophobic acrylic IOLs (p = 0.000, p < 0.05).
Conclusions:
MPC-modified hydrophilic silicone IOLs reduce silicone oil adherence, and thus may meet the need of a foldable IOL suitable for vitreoretinal patients.
