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Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Updated: May 21, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Autoantibodies in systemic sclerosis.

Sonal Mehra¹, Jennifer Walker, Karen Patterson

¹Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary, Alberta, Canada, T2N 4N1.

Autoimmunity Reviews

|June 30, 2012

Summary

This summary is machine-generated.

Systemic sclerosis (SSc) is characterized by autoantibodies. This review details their history, clinical associations, and pathogenic roles, noting new technologies are re-evaluating SSc autoantibody complexity.

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Area of Science:

Immunology
Rheumatology
Serology

Background:

Autoantibodies targeting nuclear, cytoplasmic, and extracellular autoantigens are key serological markers of systemic sclerosis (SSc).
The complexity of autoantibody profiles in SSc was previously considered less diverse compared to other systemic autoimmune rheumatic diseases.

Purpose of the Study:

To provide a comprehensive overview of the history and clinical associations of autoantibodies identified in systemic sclerosis (SSc) sera.
To examine the evolving understanding of SSc autoantibody complexity in light of technological advancements.

Main Methods:

Review of existing literature on autoantibodies in systemic sclerosis (SSc).
Discussion of historical perspectives and clinical correlations.
Examination of the impact of advanced array technologies on autoantibody detection.

Main Results:

Numerous autoantibodies have been identified in SSc, with varying roles in pathogenesis, some preceding clinical diagnosis.
Emerging array technologies enable the detection of multiple autoantibodies in individual sera, challenging previous assumptions about SSc serological complexity.
The heterogeneity of B cell responses in SSc is being re-evaluated through advanced detection methods.

Conclusions:

Autoantibodies are central to the serological diagnosis and understanding of systemic sclerosis (SSc).
The advent of array technologies is refining our comprehension of the diverse autoantibody spectrum in SSc, necessitating a re-examination of established immunological tenets.
Further research into the pathogenic roles and clinical significance of specific autoantibodies in SSc is warranted.