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Psychosurgery

Psychosurgery

Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...

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Updated: May 21, 2026

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery

Published on: January 6, 2011

Deep-brain stimulation for aggressive and disruptive behavior.

Angelo Franzini¹, Giovanni Broggi, Roberto Cordella

¹Department of Neurosurgery, Fondazione IRCCS Istituto Nazionale Neurologico Carlo Besta, Milan, Italy.

World Neurosurgery

|June 30, 2012

Summary

This summary is machine-generated.

Deep-brain stimulation (DBS) of the posterior hypothalamus effectively reduced aggressive behavior in patients with mental retardation. This treatment simplified management for six of seven patients refractory to other therapies.

Keywords:

Aggressive behavior CT Computed tomography DBS Deep brain stimulation Deep-brain stimulation MRI Magnetic resonance Imaging Posterior hypothalamus pHyp

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Area of Science:

Neurosurgery
Behavioral Neurology
Psychiatry

Background:

Aggressive and disruptive behaviors can be refractory to conservative treatments.
Mental retardation can coexist with severe behavioral issues.

Purpose of the Study:

To evaluate the efficacy of deep-brain stimulation (DBS) in treating severe, treatment-refractory aggressive and disruptive behaviors.
To describe institutional experience with posterior hypothalamic DBS.

Main Methods:

Seven patients received bilateral DBS in the posterior hypothalamic region under general anesthesia.
Stereotactic methodology and intraoperative microrecording were utilized.
Treatment was administered between 2002 and 2010.

Main Results:

Six out of seven patients showed a significant reduction in aggressive and disruptive episodes.
The simplification of family management was a notable outcome.
No specific adverse events were detailed in the abstract.

Conclusions:

Posterior hypothalamic DBS may be a viable treatment for disruptive, drug-refractory aggression in patients with mental retardation.
Further research is needed to confirm long-term efficacy and safety.
The posterior hypothalamic region shows promise as a DBS target for specific behavioral disorders.