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Hierarchical organization and regulation of the hematopoietic stem cell osteoblastic niche

Hongxu Wang1, Penghui Zhang, Lin Liu

  • 1Center for Clinical Molecular Medicine, Chongqing Medical University, Chongqing 400014, China.

Critical Reviews in Oncology/Hematology
|June 30, 2012
PubMed

Hematopoietic stem cells (HSCs) are characterized with long-term self-renewal and multi-lineage differentiation. HSCs preferentially reside in osteoblastic niche that is hierarchically organized so as to exactly regulate HSCs properties and maintain organism hematopoietic homeostasis. Hematopoietic stem cell-mesenchymal stem cell pairings share stem cell niches in adult bone marrow under immune-humoral-neural regulation. Here, we review the hierarchical HSC osteoblastic niche in terms of its localization, composition, function, and multi-layer regulation systems.

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