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[Abnormal glucose tolerance in prepubertal patients with cystic fibrosis]

M Martín-Frías1, A Lamas Ferreiro, P Enes Romero

  • 1Unidad de Diabetes Pediátrica, Servicio de Pediatría, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Madrid, España. mmartinf.hrc@salud.madrid.org

Anales De Pediatria (Barcelona, Spain : 2003)
|June 30, 2012
PubMed

Insights

Abnormal glucose tolerance (AGT) is common in young cystic fibrosis (CF) patients, often preceding declines in lung function. Early screening for AGT in CF children is recommended due to its significant clinical impact.

Area of Science:

  • Pediatric Endocrinology
  • Cystic Fibrosis Research
  • Metabolic Disorders

Context:

  • Current guidelines recommend annual screening for abnormal glucose tolerance (AGT) in cystic fibrosis (CF) patients starting at age 10.
  • Prepubertal CF patients represent a critical window for understanding early metabolic changes.

Purpose:

  • To determine the prevalence of AGT in prepubertal CF patients.
  • To assess the clinical outcomes of AGT in this population.
  • To analyze changes in glycemic control, nutritional status, and lung function over one year.

Summary:

  • A retrospective study of 19 prepubertal CF patients revealed that 47% had AGT at initial screening (mean age 8.5 years).
  • Over a 2-year follow-up, new cases of AGT emerged, and a significant proportion of AGT patients experienced declining BMI-SDS and/or lung function.
  • AGT patients exhibited a lower insulinogenic index, suggesting delayed insulin secretion.

Impact:

  • The high frequency of AGT in prepubertal CF patients underscores the need for earlier glycemic screening.
  • Early detection and management of AGT may help mitigate negative clinical outcomes, including impaired lung function and nutritional decline.
  • Findings support revising current screening recommendations for CF patients to an earlier age.
Abstract

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