Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
Recrystallization: Solid–Solution Equilibria01:10

Recrystallization: Solid–Solution Equilibria

4.1K
Recrystallization is a purification technique used to separate impurities from solid compounds. In this technique, no chemical reactions occur. Instead, it exploits physical properties only, specifically, the solubility differences between the desired compound and impurities, either at a single temperature or at different temperatures, and under other selected conditions. The solid-solution equilibrium (solubility equilibrium) of each component in the solution represents a binary phase...
4.1K
Crystal Growth: Principles of Crystallization01:25

Crystal Growth: Principles of Crystallization

5.7K
Crystallization is a phase transformation process in which crystals are precipitated from a supersaturated solution or formed from other sources. During crystallization, atoms or molecules arrange themselves into a well-defined, rigid crystal lattice to minimize energy.
Initiating crystallization involves manipulating the concentration of the solute and the temperature of the solution. Since crystal growth occurs when the ratio of concentration and solubility of the solute in the solvent...
5.7K
The Bone Matrix01:18

The Bone Matrix

9.4K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
9.4K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

6.2K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.2K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

8.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the association between pressure ulcers and sitting in adults: What does it mean for all of us?

Journal of tissue viability·2025
Same author

Modification and validation of the Bluebelle Wound Healing Questionnaire (WHQ) for assessing surgical site infection in wounds healing by secondary intention.

Journal of tissue viability·2025
Same author

The development of international wound debridement best practice recommendations: Consensus between nurses specialized in Wound, Ostomy and Continence Canada and the society of tissue viability.

Journal of tissue viability·2024
Same author

A proof-of-concept study applying machine learning methods to putative risk factors for eating disorders: results from the multi-centre European project on healthy eating.

Psychological medicine·2021
Same author

Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set.

Annals of oncology : official journal of the European Society for Medical Oncology·2021
Same author

The Identification of Low-risk Gambling Limits for Specific Gambling Activities.

Journal of gambling studies·2021
Same journal

Zinc-polydopamine nanozyme promotes mitochondrial biogenesis and alleviates inflammation and muscle atrophy during the perioperative period of surgery.

Journal of materials science. Materials in medicine·2026
Same journal

Immuno-instructive biomaterials for coronary artery disease and myocardial infarction repair.

Journal of materials science. Materials in medicine·2026
Same journal

Effect of topical nanoemulsion of minoxidil on animal hair growth: an in vivo study.

Journal of materials science. Materials in medicine·2026
Same journal

Selective cytotoxicity of zinc peroxide and tetrapodal zinc oxide micro-nanoparticles against breast cancer cells: synthesis, characterization, and therapeutic potential.

Journal of materials science. Materials in medicine·2026
Same journal

Progress and challenges of tantalum-containing biomaterials in regenerative medicine applications.

Journal of materials science. Materials in medicine·2026
Same journal

Synchronizing degradation with regeneration: a model-driven framework for designing biodegradable biomaterials in bone tissue engineering.

Journal of materials science. Materials in medicine·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

8.7K

Bone mineral crystallisation kinetics.

C Greenwood1, K Rogers, S Beckett

  • 1Department of Engineering and Applied Science, Cranfield University, Shrivenham, Wiltshire, SN6 8LA, UK. c.greenwood@cranfield.ac.uk

Journal of Materials Science. Materials in Medicine
|June 30, 2012
PubMed
Summary
This summary is machine-generated.

This study reveals the organic matrix in bone actively promotes apatite crystallization, rather than protecting it. Bone apatite crystallization kinetics were quantified, showing temperature-dependent diffusion processes.

More Related Videos

Calcium Carbonate Formation in the Presence of Biopolymeric Additives
09:31

Calcium Carbonate Formation in the Presence of Biopolymeric Additives

Published on: May 14, 2019

16.7K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

6.6K

Related Experiment Videos

Last Updated: May 1, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
14:55

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

8.7K
Calcium Carbonate Formation in the Presence of Biopolymeric Additives
09:31

Calcium Carbonate Formation in the Presence of Biopolymeric Additives

Published on: May 14, 2019

16.7K
Optimization of Crystal Growth for Neutron Macromolecular Crystallography
12:29

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

6.6K

Area of Science:

  • Biomineralization
  • Materials Science
  • Bone Biology

Background:

  • Bone apatite crystallization is crucial for bone mechanical properties.
  • Understanding the role of the organic matrix in biomineralization is essential.

Purpose of the Study:

  • To quantitatively analyze bone apatite crystallization kinetics.
  • To determine the influence of the organic matrix on apatite formation.

Main Methods:

  • Utilized X-ray diffraction for analyzing bovine, porcine, and anorganic bone.
  • Applied the Johnson-Mehl-Avrami (JMA) model with apatite coherence length as the independent variable.

Main Results:

  • A direction-averaged crystallization activation energy of 183 ± 8 kJ mol⁻¹ was observed across all bone groups.
  • The JMA 'n' exponent decreased with increasing temperature, indicating a shift to diffusion-limited crystallization.
  • Evidence suggests the organic matrix promotes, rather than protects, apatite crystallization.

Conclusions:

  • The organic matrix plays an active role in promoting bone apatite crystallization.
  • Bone apatite crystallization kinetics are temperature-dependent and can become diffusion-limited.
  • Novel quantitative methods provide new insights into bone biomineralization processes.