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Prospective evaluation of 1-day polyethylene glycol-3350 bowel preparation regimen in children

Mazen I Abbas1, Cade M Nylund, Carol J Bruch

  • 1Department of Pediatrics, Walter Reed National Military Medical Center, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA. mazen.abbas@us.army.mil

Journal of Pediatric Gastroenterology and Nutrition
|June 30, 2012
PubMed

Insights

A fast-acting pediatric colonoscopy prep using polyethylene glycol-3350 (PEG-3350) and Gatorade proved effective and safe for children. While generally well-tolerated, the large volume was a noted drawback.

Area of Science:

  • Pediatric Gastroenterology
  • Endoscopy Procedures
  • Gastrointestinal Motility Disorders

Background:

  • Effective bowel preparation is crucial for successful pediatric colonoscopy.
  • Traditional bowel prep regimens can be challenging for children to tolerate.
  • Novel, faster-acting preparations are needed to improve compliance and efficacy.

Purpose of the Study:

  • To evaluate the efficacy, safety, and tolerability of a rapid pediatric colonoscopy bowel preparation.
  • The regimen combined polyethylene glycol-3350 (PEG-3350) with a sports drink (Gatorade).
  • Assessment focused on preparation quality, adverse events, and patient acceptance.

Main Methods:

  • A prospective, open-label trial involving 46 children aged 8-18 years.
  • Participants received 238 g of PEG-3350 mixed with 1.9 L of Gatorade, consumed over a few hours.
  • Efficacy was measured by the Boston Bowel Preparation Scale; safety and tolerability were assessed via questionnaires and metabolic profiles.

Main Results:

  • 93.5% of patients completed the regimen, leading to successful colonoscopies in all cases (cecal intubation).
  • 77% of preparations were deemed effective, with 84% achieving terminal ileum visualization.
  • The most common adverse effects were nausea/vomiting (60%), abdominal pain (44%), and fatigue (40%); no significant metabolic changes occurred.

Conclusions:

  • The PEG-3350 and Gatorade regimen is an effective and safe bowel preparation for pediatric colonoscopy.
  • Moderate tolerability was observed, with the large fluid volume being the primary concern.
  • This rapid regimen offers a viable option for improving pediatric colonoscopy preparation.
Abstract

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