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Related Concept Videos

Three-Domain System of Life01:21

Three-Domain System of Life

Ribosomal RNA (rRNA) sequence analysis revealed three distinct groups of cells: eukaryotes, bacteria, and archaea. In 1978, Carl R. Woese proposed the concept of domains, a taxonomic level above kingdoms, to differentiate these groups. He suggested that archaea and bacteria, despite their similar appearance, represent separate domains. Domains differ in rRNA, membrane lipid structure, transfer RNA, and antibiotic sensitivity.In this classification, animals, plants, and fungi belong to the...
Characteristics of Life01:23

Characteristics of Life

Biology is a natural science that studies life and living organisms, including their structure, function, development, interactions, evolution, distribution, and taxonomy. The field's scope is extensive and divided into several specialized disciplines, such as anatomy, physiology, ethology, genetics, and many more. All living things share a few key traits, including cellular organization, heritable genetic material and the ability to adapt/evolve, metabolism to regulate energy needs, the...
Membrane Domains01:18

Membrane Domains

The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the anterior...
The Tree of Life - Bacteria, Archaea, and Eukaryotes02:40

The Tree of Life - Bacteria, Archaea, and Eukaryotes

The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both extant and...
Levels of Organization01:09

Levels of Organization

Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...

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Related Experiment Video

Updated: May 20, 2026

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
12:04

Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing

Published on: October 3, 2018

Life sciences domain analysis model.

Robert R Freimuth1, Elaine T Freund, Lisa Schick

  • 1Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

Journal of the American Medical Informatics Association : JAMIA
|June 30, 2012
PubMed
Summary
This summary is machine-generated.

The Life Sciences Domain Analysis Model (LS DAM) enhances biomedical research communication by providing common semantics. Harmonized with the BRIDG model, it improves data exchange for translational science.

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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
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Area of Science:

  • Biomedical research
  • Life sciences
  • Translational research

Background:

  • Effective information exchange is crucial for collaborative biomedical research.
  • Developing standardized information systems is essential for supporting research endeavors.
  • Existing models may not fully capture the nuances of life sciences research.

Purpose of the Study:

  • To develop the Life Sciences Domain Analysis Model (LS DAM) as a framework for communication in biomedical research.
  • To harmonize the LS DAM with the Biomedical Research Integrated Domain Group (BRIDG) model.
  • To facilitate data exchange for translational research through integrated models.

Main Methods:

  • The LS DAM was developed by analyzing life sciences and translational research scenarios.
  • Concepts were derived from existing information models, reference models, and data exchange formats.
  • The model is represented using the Unified Modeling Language and ISO 21090 data types.

Main Results:

  • The LS DAM v2.2.1 includes 130 classes covering core areas like Experiment, Molecular Biology, Molecular Databases, and Specimen.
  • Approximately 50% of LS DAM classes are derived from the BRIDG model, ensuring semantic harmonization.
  • Validation confirmed the LS DAM's general applicability for representing life sciences research.

Conclusions:

  • The LS DAM offers unambiguous definitions for describing life sciences research concepts.
  • Harmonization with BRIDG promotes interoperability in translational science.
  • The consensus-building process used for LS DAM development can be applied to future standardization efforts.