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Updated: May 20, 2026

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
Published on: January 16, 2018
The future of ciliary and flagellar membrane research
1Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. rab4m@virginia.edu
Abstract:
There has been a dramatic shift of attention from the ciliary axoneme to the ciliary membrane, much of this driven by the appreciation that cilia play a widespread role in sensory reception and cellular signaling. This Perspective focuses attention on some of the poorly understood aspects of ciliary membranes, including the establishment of ciliary and periciliary membrane domains, the trafficking of membrane components into and out of these membrane domains, the nonuniform distribution of ciliary membrane components, the regulation of membrane morphogenesis, functional collaboration between the axoneme and the membrane, and the evolving field of therapeutics targeted at the ciliary membrane.
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