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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Updated: May 20, 2026

Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models
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Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models

Published on: September 6, 2024

An evolving role for DEPTOR in tumor development and progression.

Zhiwei Wang1, Jiateng Zhong, Hiroyuki Inuzuka

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Neoplasia (New York, N.Y.)
|June 30, 2012
PubMed
Summary

DEPTOR, an mTOR inhibitor, plays a key role in cancer development. Its stability, regulated by SCF(β-TrCP), impacts mTOR signaling, offering a potential target for novel anticancer treatments.

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Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
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Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

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Last Updated: May 20, 2026

Unveiling Therapeutic Opportunities with Melanoma Patient-derived Organoid Models
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Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
08:11

Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics

Published on: March 26, 2018

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Deregulation of the mammalian target of rapamycin (mTOR) pathway is common in human cancers.
  • The precise regulatory mechanisms of the mTOR pathway are not fully understood.
  • DEPTOR has been identified as an endogenous inhibitor of mTOR activity.

Purpose of the Study:

  • To review the literature on DEPTOR's function in cancer pathogenesis.
  • To explore DEPTOR's role in cellular processes relevant to cancer, including growth, apoptosis, autophagy, epithelial-mesenchymal transition, and drug resistance.
  • To discuss the potential of targeting DEPTOR as an anticancer strategy.

Main Methods:

  • Literature review of recent studies on DEPTOR and mTOR signaling.
  • Analysis of DEPTOR's involvement in key cancer-related cellular processes.
  • Summary of evidence linking DEPTOR stability and cancer progression.

Main Results:

  • DEPTOR inhibits mTOR activity and plays a critical role in human malignancies.
  • DEPTOR stability is regulated by the SCF(β-TrCP) E3 ubiquitin ligase.
  • Disrupted DEPTOR degradation can lead to mTOR hyperactivation in cancer.

Conclusions:

  • DEPTOR is implicated in various aspects of cancer pathogenesis, including cell growth, apoptosis, autophagy, EMT, and drug resistance.
  • Targeting DEPTOR presents a promising novel strategy for cancer therapy.