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Updated: May 20, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Isolactarane and sterpurane sesquiterpenoids from the basidiomycete Phlebia uda
Anja Schüffler1, Beate Wollinsky, Timm Anke
1Institute of Biotechnology and Drug Research (IBWF), Erwin-Schrödinger-Strasse 56, 67663 Kaiserslautern, Germany.
Abstract:
Three new sesquiterpenoids, named udasterpurenol A, udalactarane A, and udalactarane B, as well as the known compounds hyphodontal and sterpuric acid have been isolated from the basidiomycete Phlebia uda. These compounds represent the first natural products described from this species. The structures were elucidated by NMR spectroscopy and mass spectrometry. Udalactaranes A and B were isolated as mixtures with their respective epimeric acetals. These mixtures inhibited the spore germination of the plant pathogenic fungus Fusarium graminearum at 10 and 5 μg/mL, respectively, and were active against Jurkat cells with IC(50) values of 101 and 42 μM, respectively.
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