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Updated: May 20, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Contact dermatitis in a child from methlychloroisothiazolinone and methylisothiazolinone in moist wipes
Jana Kazandjieva1, Malena Gergovska, Razvigor Darlenski
1Department of Dermatology and Venereology, Medical Faculty, Medical University, Sofia, BulgariaDepartment of Dermatology and Venereology, Tokuda Hospital, Sofia, Bulgaria.
Abstract:
Contact allergic reactions to methlychloroisothiazolinone/methylisothiazolinone also widely known as Kathon CG have been reported extensively reported. It is one of the most commonly used preservatives in rinse-off products, cosmetics, and others. Herein, a case of a 50-year-old girl is presented with chronic dermatitis in the anogenital area. The patient was patch tested and had positive reaction to Kathon CG. The detailed history taking revealed that the allergen was present in the moist cleaning wipes used instead of dry toilet paper. The presented case serves as a basis for a appraisal of the use of this preservative in wet wipes. In addition, the duration of the patch test protocol in children has also been discussed.
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