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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
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Hormones and Bone Tissue01:17

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Related Experiment Video

Updated: May 20, 2026

A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
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A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model

Published on: August 18, 2023

[Gap junctions and bone remodeling].

Julie Talbot1, Franck Verrecchia

  • 1INSERM, UMR 957, Université de Nantes, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculté de Médecine, CHU de Nantes, Nantes, France.

Biologie Aujourd'Hui
|July 4, 2012
PubMed
Summary
This summary is machine-generated.

Gap junctions, formed by connexins, facilitate cell communication. This review explores their role in bone remodeling, highlighting connexin 43

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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A 3-D Visualization Technique for Bone Remodeling in a Suture Expansion Mouse Model
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Published on: February 28, 2017

Area of Science:

  • Cell Biology
  • Biochemistry
  • Bone Physiology

Context:

  • Gap junctions are transmembrane channels connecting adjacent cell cytoplasms.
  • These junctions mediate the exchange of ions and small molecules (<1200 Da).
  • Each channel comprises two connexons, hexameric assemblies of connexin proteins.

Purpose:

  • To review the structure of gap junctions and their role in bone remodeling.
  • To discuss the mechanisms regulating bone remodeling processes.
  • To present evidence for gap junctional intercellular communication in bone remodeling.

Summary:

  • Connexins are homologous proteins forming gap junction channels; Connexin 43 is the primary gap junction protein in human bone cells.
  • Bone remodeling involves coordinated osteoblast (bone-forming) and osteoclast (bone-resorbing) activity.
  • This review synthesizes current knowledge on gap junction structure and bone remodeling, suggesting a functional contribution of intercellular communication.

Impact:

  • Provides a comprehensive overview of gap junction function in skeletal biology.
  • Highlights the potential therapeutic target of gap junctions in bone diseases.
  • Facilitates understanding of cellular communication in maintaining bone homeostasis.