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Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

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Isolated left ventricular noncompaction in identical twins.

Ferande Peters¹, Bijoy K Khandheria, Claudia dos Santos

¹Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand, Johannesburg, South Africa.

The American Journal of Cardiology

|July 4, 2012

Summary

This study reports the first case of adult monozygotic twins diagnosed with isolated left ventricular noncompaction. Both twins experienced similar heart failure symptoms and echocardiographic findings.

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Area of Science:

Cardiology
Genetics
Cardiovascular Imaging

Background:

Left ventricular noncompaction is a rare congenital cardiomyopathy.
Monozygotic twins share identical genetic material, offering a unique model for studying genetic influences on cardiac diseases.

Observation:

The case involves 35-year-old monozygotic twins presenting with heart failure.
The twins presented with similar clinical manifestations and echocardiographic features of left ventricular noncompaction.

Findings:

This is the first reported instance of adult monozygotic twins with isolated left ventricular noncompaction.
Both individuals exhibited abnormal cardiac twist mechanics.
Similar clinical and echocardiographic presentations were observed in both twins.

Implications:

This case highlights the potential genetic predisposition to left ventricular noncompaction in twins.
Further research into the genetic and environmental factors influencing noncompaction development is warranted.
Understanding shared genetic factors may aid in early diagnosis and risk stratification for familial cases.