Relation between adiponectin and brain natriuretic peptide in healthy pediatric subjects: from birth through
C Caselli1, M Cantinotti, S Del Ry
1Consiglio Nazionale delle Ricerche (CNR), Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa Research Area, Via G. Moruzzi 1, 56100 Pisa, Italy.
Insights
Adiponectin levels are higher in children than adults and decrease with age. This age-dependent adiponectin profile in children correlates with Brain Natriuretic Peptide (BNP) levels.
Area of Science:
- Pediatric endocrinology
- Cardiovascular biomarkers
- Metabolic regulation
Background:
- Cardiovascular disease biomarkers require further understanding in pediatric populations.
- Adiponectin plays a role in metabolism and possesses anti-inflammatory and anti-atherogenic properties.
Purpose of the Study:
- To investigate circulating adiponectin levels throughout childhood growth.
- To examine the relationship between adiponectin and Brain Natriuretic Peptide (BNP) in healthy children.
Main Methods:
- Plasma adiponectin and BNP were measured in 131 healthy children across different age groups (newborns, neonates, infants, children) and 33 adults.
- Statistical analysis was performed to compare groups and assess correlations.
Main Results:
- Children exhibited significantly higher plasma adiponectin levels compared to adults.
- Adiponectin levels showed a progressive decrease with age, with three distinct age-based reference intervals identified.
- Both adiponectin and BNP levels decreased with growth, demonstrating a significant positive correlation.
Conclusions:
- Pediatric adiponectin plasma levels are age-dependent, with established reference intervals.
- The observed age-dependent pattern of adiponectin in children may be influenced by BNP levels.
Background And Aims:
New biomarkers potentially improve clinical management of cardiovascular disease, but there are gaps in understanding their role during childhood. Adiponectin regulates metabolism and exerts anti-inflammatory/anti-atherogenic effects. The aim of the study was to evaluate circulating levels of adiponectin during postnatal growth and its relationship with Brain Natriuretic Peptide (BNP) in healthy children, a marker of cardiac function known to be increased in childhood.
Methods And Results:
Plasma adiponectin and BNP were measured in 131 healthy children divided into: 43 newborns (0-3 days), 29 neonates (4-30 days), 25 infants (1-12 months) and 34 children (1-12 years). A group of 33 healthy adult subjects (25-60 years) was also studied. Plasma adiponectin in the 131 children resulted significantly higher compared to adult subjects (p < 0.0001). The time-course of adiponectin suggests the design of three age-based intervals: the first until 1 month of age (median 29.07 μg/mL, 11.61-47.01 μg/mL 5°-95° percentiles), the second between 1 and 12 months of age (21.66 μg/mL, 8.83-59.81 μg/mL) and the third for age up to 12 years (13.81 μg/mL, 4.10-28.57 μg/mL). Both adiponectin and BNP exhibited the same trend of a progressive decrease during growth, showing a significant relationship (Spearman's rho = 0.403, p < 0.0001).
Conclusion:
Adiponectin plasma levels in a healthy pediatric population vary as a function of age. Three reference intervals for adiponectin in pediatric subjects have been indicated. The relationship between adiponectin and BNP suggests that the age-dependent profile of circulating adiponectin could also be due to BNP.
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