Subclinical hypothyroidism and myocardial function in obese children
C Brienza1, A Grandone, G Di Salvo
1Department of Pediatrics, Second University of Naples, Via De Crecchio 4, 80138 Naples, Italy.
Summary
Pediatric obesity-related Subclinical Hypothyroidism (SCH) is linked to impaired cardiac function in children. Obese children with SCH showed reduced systolic and diastolic function, suggesting potential cardiovascular risks.
Area of Science:
- Pediatric Endocrinology
- Cardiology
- Metabolic Disorders
Background:
- Pediatric obesity is a growing global health concern.
- Isolated Hyperthyreotropinemia, or Subclinical Hypothyroidism (SCH), is common in obese children.
- SCH in adults is associated with impaired myocardial function.
Purpose of the Study:
- To investigate the impact of obesity-related SCH on myocardial function in children.
- To determine if SCH influences cardiac performance in pediatric obesity.
Main Methods:
- Doppler echocardiography was used to assess myocardial function.
- 34 obese children with SCH and 60 obese children without SCH were studied.
- Evaluated global systolic function (Ejection Fraction) and diastolic function.
Main Results:
- Global systolic function (EF) was similar between groups.
- Reduced Right Ventricle systolic function and pressure in the SCH group.
- Significant reductions in Mitral Annulus Peak Systolic excursion and Tissue Doppler Imaging peak systolic motion (TDI-S) in the SCH group.
- Abnormalities in diastolic function were observed in the SCH group.
Conclusions:
- Obesity-related SCH in children may involve impaired cardiac function.
- Findings suggest abnormal diastolic function and reduced longitudinal systolic function in pediatric SCH.
- These results may alter clinical management of obese children with SCH.
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