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Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA

Hana Hájková1, Jana Marková, Cedrik Haškovec

  • 1Institute of Hematology and Blood Transfusion, Prague, Czech Republic. hana.hajkova@uhkt.cz

Leukemia Research
|July 4, 2012
PubMed

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Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...