Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
Physical Properties of Amines01:26

Physical Properties of Amines

Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circular inference in visual cortical hierarchies in schizophrenia.

Psychiatry and clinical neurosciences·2026
Same author

Subjective sleepiness and objective sleep propensity in adults with attention-deficit/hyperactivity disorder referred for multiple sleep latency testing.

Frontiers in psychiatry·2026
Same author

Inattention and hyperfocus mediate the association between prefrontal cortical thickness and problematic usage of the internet, with frequent gaming-related problems, independent of a formal ADHD diagnosis.

Journal of psychiatric research·2026
Same author

Before Diagnostic Closure: State-Forming Information in Psychiatric Assessment.

Psychotherapy and psychosomatics·2026
Same author

Identification of autoantibodies against L1CAM in patients with schizophrenia.

Brain, behavior, & immunity - health·2026
Same author

An integrative NLP framework identifies multilevel linguistic phenotypes of schizophrenia across tasks.

Psychological medicine·2026

Related Experiment Video

Updated: May 20, 2026

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

Monoamines and assessment of risks.

Hidehiko Takahashi1

  • 1Department of Psychiatry, Kyoto University Graduate School of Medicine, 54 Shogoin, Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan. hidehiko@kuhp.kyoto-u.ac.jp

Current Opinion in Neurobiology
|July 4, 2012
PubMed
Summary

Neuroeconomics research reveals how neurotransmitters like dopamine, noradrenaline, and serotonin influence decision-making. These monoamines are linked to how we perceive reward probability and react to potential losses.

Area of Science:

  • Neuroeconomics
  • Neuroscience
  • Decision Science

Background:

  • Neuroeconomics studies using fMRI or EEG have elucidated the neural underpinnings of decision-making.
  • A key unanswered question concerns the role of modulatory neurotransmission in these processes.
  • Prospect theory offers an alternative to normative decision theory, explaining observed biases.

Purpose of the Study:

  • To investigate the relationship between central monoamine transmission and key features of prospect theory.
  • Specifically, to explore the roles of dopamine, noradrenaline, and serotonin in nonlinear probability weighting and loss aversion.

Main Methods:

  • Review of recent neuroeconomics research.
  • Focus on studies examining monoamine systems (dopamine, noradrenaline, serotonin).

More Related Videos

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
13:35

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites

Published on: March 1, 2018

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

Related Experiment Videos

Last Updated: May 20, 2026

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices
07:56

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Published on: August 11, 2021

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
13:35

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites

Published on: March 1, 2018

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

  • Analysis of evidence linking neurotransmitter tone to prospect theory parameters.

    • Main Results:

    • Circumstantial evidence suggests dopamine tone may correlate with subjective reward probability distortion.
    • Noradrenaline and serotonin tone appear to influence reactions to potential losses.
    • These findings connect monoamine function to non-normative decision-making biases.

    Conclusions:

    • Modulatory neurotransmission, particularly via monoamines, plays a crucial role in economic decision-making.
    • Understanding these neurochemical influences is vital for advancing neuroeconomics and behavioral economics.
    • Future research should further elucidate the precise mechanisms linking neurotransmitters to prospect theory constructs.