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Updated: May 20, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Two cases of tuberculosis with multiple drug hypersensitivity after drug-induced hypersensitivity syndrome
Akimasa Sekine1, Takefumi Saito, Shusaku Ito
1Department of Respiratory Medicine, National Hospital Organization, Ibaraki-Higashi National Hospital, Terunuma 825, Tokai-mura, Naka-gun, Ibaraki, Japan. Akimasa.Sekine@gmail.com
Abstract:
Here, we report 2 cases of drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine and allopurinol during tuberculosis treatment. Both patients also developed multiple drug hypersensitivity (MDH) to several antituberculosis drugs that were used at around the period of DIHS onset, and thus, the treatment could not be successfully completed. Our cases show that MDH can easily occur after development of DIHS. Considering that treatment for tuberculosis requires long-term management with several drugs, it is important to refrain from administering drugs that can cause DIHS during tuberculosis treatment.
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