Bystanders not so innocent after all

Marcel Batten1, Nico Ghilardi

  • 1Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia.

Immunity
|July 4, 2012
PubMed

Interleukin 27 (IL-27) regulates immune responses, including T helper 17 (Th17) cell activity. In this issue of Immunity, Hirahara et al. (2012) demonstrate that IL-27 suppresses Th17 cells in trans through induction of the inhibitory ligand PD-L1 on bystander T cells.

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