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Prototype PowerPlex® Y23 System: A concordance study.

Carey Davis1, Jianye Ge, Cynthia Sprecher

  • 1University of North Texas Health Science Center, Institute of Applied Genetics, Department of Forensic and Investigative Genetics, Fort Worth, TX 76107, United States. carey.davis@unthsc.edu

Forensic Science International. Genetics
|July 4, 2012
PubMed
Summary
This summary is machine-generated.

The PowerPlex® Y23 System amplifies 23 Y-STR loci for forensic analysis. It shows high concordance with the Yfiler™ kit, though DYS448 locus deletions may cause discrepancies.

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Area of Science:

  • Forensic Genetics
  • Population Genetics
  • Molecular Biology

Background:

  • The PowerPlex® Y23 System is a novel kit for Y-chromosome Short Tandem Repeat (Y-STR) analysis.
  • Y-STR profiling is crucial in forensic science for identifying individuals and determining paternal lineage.

Purpose of the Study:

  • To evaluate the performance of the Prototype PowerPlex® Y23 System.
  • To assess concordance between the PowerPlex® Y23 System and the AmpFlSTR® Yfiler™ kit.
  • To analyze Y-STR profiles across diverse populations.

Main Methods:

  • Polymerase chain reaction (PCR)-based amplification of 23 Y-STR loci.
  • Typing of 951 samples from six distinct populations.
  • Concordance analysis for 17 shared loci between the two kits.

Main Results:

  • High overall concordance was observed between the PowerPlex® Y23 System and the Yfiler™ kit.
  • A total of 16,167 loci were analyzed, demonstrating the kit's robustness.
  • Discordant calls can occur at the DYS448 locus due to deletions, necessitating careful interpretation.

Conclusions:

  • The PowerPlex® Y23 System is a valuable tool for forensic laboratories, enabling analysis of a wide range of Y-STR loci.
  • Users must be aware of potential nomenclature anomalies, particularly at the DYS448 locus, when comparing profiles.
  • The kit utilizes established technologies, facilitating integration into existing forensic workflows.