Related Experiment Video
Updated: May 20, 2026
The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension
Published on: May 17, 2024
Homocysteine level and risk of fracture: A meta-analysis and systematic review
Jun Yang1, Xinhua Hu, Qiang Zhang
1Department of Surgery, First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Aims:
Previous studies have reported inconsistent findings regarding the association between elevated plasma Hcy levels and fracture risk. We investigated this association between homocysteine (Hcy) levels in patients with fracture and unaffected controls by conducting a meta-analysis and systematic review.
Methods:
We conducted a systematic literature search (up to April 2012) of the PubMed database and Embase. We selected observational studies that evaluated Hcy levels in subjects with fracture compared to unaffected controls. We also included randomized clinical trials (RCTs) on the effect of Hcy-lowering therapy in fracture patients. Criteria for inclusion were the assessment of baseline Hcy and risk of fracture as an outcome. The results were presented as relative risk (RR) and corresponding 95% confidence intervals (CI) comparing fracture patients to the control subjects or the highest Hcy quartile group to the lowest Hcy quartile group.
Results:
Nine studies with 14,863 participants were identified and analyzed. The pooled RR from a random effect model of participants with all fractures compared with the control subjects was 1.59 (95% CI 1.30-1.96). The pooled RR from a random model for hip fractures in the highest Hcy quartile group compared with the lowest Hcy quartile group was 1.67 (95% CI 1.17-2.38). The effect of Hcy-lowering therapy on fracture was tested in two clinical trials, but clinically important end points were not reported in a consistent way.
Conclusions:
This meta-analysis and systematic review suggested that Hcy significantly increased the risk of fracture, and the increase was independent of risk factors.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:25Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism