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Updated: May 20, 2026

Chemical Dimerization-Induced Protein Condensates on Telomeres
Published on: April 12, 2021
PinX1 is involved in telomerase recruitment and regulates telomerase function by mediating its localization
Derek Hang-Cheong Cheung1, Hsiang-Fu Kung, Jun-Jian Huang
1Biochemistry Programme, School of Life Sciences and Centre for Protein Science and Crystallography, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
Abstract:
Telomerase recruitment to telomere is the prerequisite for telomere extension, but the proteins involved in this process are still largely unknown. PinX1 is a telomerase inhibitor and has been implicated in telomere maintenance. Silencing of PinX1 significantly reduced the localization of telomerase to telomere during mid-late S phase, suggesting the involvement of PinX1 in the cell cycle-dependent trafficking of hTERT to telomere. We also revealed that PinX1 mediated the chromosomal localization of hTERT during anaphase. This study revealed the role of PinX1 in telomerase function regulation by mediating its localization inside cells.
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