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P42-influence of TGF-ß1 and culturing medium on ALP expression in human pulp fibroblasts with different root

N Korneli1, U Hempel, R Koch

  • 1TU Dresden, Clinic of Conservative Dentistry, Fetscherstrasse 74, 01307 Dresden, Germany. Nicole.Korneli@uniklinikum-dresden.de

Bulletin Du Groupement International Pour La Recherche Scientifique En Stomatologie & Odontologie
|July 4, 2012
PubMed
Abstract

No abstract available in PubMed .

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...

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