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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Aiolos promotes TH17 differentiation by directly silencing Il2 expression

Francisco J Quintana1, Hulin Jin, Evan J Burns

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. fquintana@rics.bwh.harvard.edu

Nature Immunology
|July 4, 2012
PubMed
Summary

Researchers identified a key mechanism controlling T helper 17 (T(H)17) cell development. Aiolos transcription factor actively suppresses interleukin-2 (IL-2) production, promoting T(H)17 cell differentiation and immune responses.

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