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Related Experiment Video

Updated: May 20, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

What affects anticoagulation control in patients taking warfarin?

Lindsay Smith¹, Edzard Ernst, Paul Ewings

¹East Somerset Research Consortium, West Coker, Somerset. research@esrec.nhs.uk

The British Journal of General Practice : the Journal of the Royal College of General Practitioners

|July 4, 2012

Summary

Garlic consumption does not appear to affect warfarin control, contrary to previous suggestions. However, taking multiple prescription medications may lead to poor international normalized ratio (INR) control.

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Published on: February 26, 2013

Area of Science:

Pharmacology
Geriatric Medicine
Integrative Medicine

Background:

The aging population frequently uses multiple medications, increasing the risk of adverse drug reactions.
Warfarin, a common anticoagulant, has known interactions with numerous prescription drugs.
Potential interactions between warfarin and herbal supplements like garlic warrant investigation.

Purpose of the Study:

To investigate if concurrent garlic intake impacts international normalized ratio (INR) control in patients prescribed warfarin.
To compare INR test results in patients taking both warfarin and garlic versus those taking warfarin alone.

Main Methods:

A retrospective study design was employed, analyzing data from primary care practices.
Patients on warfarin were assessed, with garlic consumers matched to non-consumers based on age, sex, and practice.
International normalized ratio (INR) results over 12 months were evaluated, considering confounding factors like diabetes and other prescribed medications.

Main Results:

No evidence indicated that garlic consumption (supplemental or culinary) is linked to increased hemorrhagic complications or poorer INR control.
Poor INR control was potentially associated with a higher number of prescribed medications, especially during prescription changes.

Conclusions:

Clinically significant interactions between warfarin and garlic intake appear unlikely based on this study.
Further research is recommended to explore the need for intensified INR monitoring during medication adjustments.