Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ethics in Research

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.

Clinical Trials

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...

Clinical Trials: Overview

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...

Longitudinal Research

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sedative Choice and Neurocognitive Outcomes After Critical Illness in Early Childhood.

JAMA network open·2026

Same author

One year quality of life outcomes in critically ill children: a multicenter prospective cohort study.

Critical care (London, England)·2026

Same author

Care and support needs of families in the first 9 months after PICU discharge: A multi-center, longitudinal, qualitative study.

Intensive & critical care nursing·2026

Same author

Sleep Health in Critically Ill Children With Acute Respiratory Failure.

AACN advanced critical care·2026

Same author

Preventing InfusAte injuries throughout a Child's Hospitalization (PATCH): Study protocol for a type 1 hybrid randomized controlled trial.

Journal of hospital medicine·2025

Same author

The Enduring Impact of the National Institute of Nursing Research and Why We Still Need It.

JAMA health forum·2025

Search research articles

Related Experiment Video

Updated: May 20, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

Clinical research: together, stronger, bolder.

Martha A Q Curley¹

¹School of Nursing, University of Pennsylvania, Philadelphia, PA 19104-4217, USA. Curley@nursing.upenn.edu

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses

|July 4, 2012

Summary

Clinical inquiry drives evidence-based practice for critically ill patients. Collaborative research, especially randomized controlled trials, is essential for advancing critical care medicine.

Area of Science:

Critical care medicine
Clinical research methodology

Background:

Clinical inquiry involves questioning, evaluating, and innovating healthcare practices using the best available data.
Critically ill patients necessitate care grounded in robust evidence, with randomized controlled trials representing the highest evidence level.

Discussion:

The current landscape of critical care research is evolving, with an increasing number of clinical trials supporting practice.
Effective clinical research in critical care mirrors practice: collaborative and multidisciplinary.

Key Insights:

A spirit of inquiry and passion for innovation are central to patient- and family-centered critical care.
Multidisciplinary collaboration is crucial for conducting high-impact clinical research in critical care settings.

More Related Videos

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

Related Experiment Videos

Last Updated: May 20, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

Outlook:

Building stronger, bolder clinical research is achievable through collective effort and a commitment to scientific advancement.
Continued focus on high-level evidence, like randomized controlled trials, will enhance patient outcomes in critical care.